C-reactive protein derived from perivascular adipose tissue accelerates injury-induced neointimal hyperplasia

Endovascular injury induces rapid phenotypic changes in perivascular adipose tissue.

OBJECTIVE Accumulating evidence suggests that adipose tissue not only stores energy but also secretes various bioactive substances called adipocytokines. Periadventitial fat is distributed ubiquitously around arteries throughout the body. It was reported that inflammatory changes in the periadventitial fat may have a direct role in the pathogenesis of vascular diseases accelerated by obesity. W...

Perivascular delivery of blebbistatin reduces neointimal hyperplasia after carotid injury in the mouse.

Proliferation and migration of smooth muscle cells (SMC) require myosin II activity; thus, we examined whether blebbistatin, a cell-permeable selective inhibitor of myosin II ATP activity, would impair neointimal hyperplasia after vascular injury. Delivery of blebbistatin via a perivascular polymer cuff reduced neointimal formation by 73% and luminal obstruction by 75% after carotid denudation ...

Perivascular Delivery of Blebbistatin Reduces Neointimal Hyperplasia Following Carotid Injury in the Mouse

Inhibition of patched-1 prevents injury-induced neointimal hyperplasia.

OBJECTIVE To determine the role of patched receptor (Ptc)-1 in mediating pulsatile flow-induced changes in vascular smooth muscle cell growth and vascular remodeling. APPROACH AND RESULTS In vitro, human coronary arterial smooth muscle cells were exposed to normal or pathological low pulsatile flow conditions for 24 hours using a perfused transcapillary flow system. Low pulsatile flow increas...

Perivascular Adipose Tissue-Derived Adiponectin Inhibits Collar-Induced Carotid Atherosclerosis by Promoting Macrophage Autophagy

OBJECTIVES Adiponectin (APN) secreted from perivascular adipose tissue (PVAT) is one of the important anti-inflammatory adipokines to inhibit the development of atherosclerosis, but the underlying mechanism has not been clarified. In this study, we aimed to elucidate how APN regulates plaque formation in atherosclerosis. METHODS AND RESULTS To assess the role of APN secreted by PVAT in athero...